Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial. Gordon, AC, et al. JAMA 2016 [paper] Why I chose this article The kidney is painfully fragile, often one of the first organs to fail in septic shock. According to the last several iterations of the Surviving Sepsis Campaign Guidelines,
Mokhtari A, Lindahl B, Smith JG, Holzmann MJ, Khoshnood A, Ekelund U. Diagnostic Accuracy of High-Sensitivity Cardiac Troponin T at Presentation Combined With History and ECG for Ruling Out Major Adverse Cardiac Events. Ann Emerg Med. 2016;68(6):649-658.e3. [paper] Why I chose this article High-sensitivity cardiac troponin T (hs-cTnT) is a relatively new biomarker assay and
Bentzer P, Griesdale DE, Boyd J, MacLean K, Sirounis D, Ayas NT. Will This Hemodynamically Unstable Patient Respond to a Bolus of Intravenous Fluids?. JAMA. 2016;316(12):1298-1309. [paper] Why I chose this article We ask this question for every critically ill patient who remains hypotensive after what we believe is adequate fluid resuscitation. Knowing techniques to reassess these
ED Management of Patients with Febrile Neutropenia: Guideline Concordant or Overly Aggressive? Baugh CW, Wang TJ, Caterino JM, et al. Academic Emergency Medicine. 2017;24(1):83-91 [paper] Why I chose this article? It’s always interesting to find something that is practice changing, reasonable, and not commonly done. This fits the bill. I was always taught to admit febrile
The Association between Limited English Proficiency and Unplanned Emergency Department Revisit Within 72 Hours. Ngai, Ka Ming et al., Annals of Emergency Medicine. August 2016: 68(3), 213 – 219 [paper] Why I chose this article? I was excited to stumble across it in Annals as I have an interest in evaluating the quality of care we provide
Randomized comparison of intravenous procainamide vs intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: The PROCAMIO study. Ortiz et al., 2016 European Heart Journal [paper] Why I chose this article? The ACLS guidelines are quite specific on how to approach unstable conditions such as cardiac arrest. They become much more vague and
Makary, Martin A., and Michael Daniel. “Medical Error Third Leading Cause of Death in the US.” Bmj 353 (2016): I2139. Print. PMID: 27143499 Wheww. That’s quite the title. 3rd leading cause of death?? Really? Background: The CDC puts together their list of most common causes of death and this determines health policy. Money and awareness is
Thank-you for attending my Grand Rounds. Below are resources that I used for my discussions. Click each header to open up the bibliography and other resources I have found helpful. Please post any questions or comments you have in the comment box below.
Journal Club: Addition of Indapamide to Frusemide Increases Natriuresis and Creatinine Clearance, but not Diuresis, in Fluid Overloaded ICU Patients.
Bihari, Shailesh, Andrew W. Holt, Shivesh Prakash, and Andrew D. Bersten. “Addition of Indapamide to Frusemide Increases Natriuresis and Creatinine Clearance, but Not Diuresis, in Fluid Overloaded ICU Patients.” Journal of Critical Care 33 (2016): 200-06. PMID: 26948252 Two caveats before we get started. Frusemide in the title is not a misprint but rather the Australian
Qureshi MD, Adnan, et al. for the ATACH-2 Trial Investigators and the Neurological Emergency Treatment Trials Network. Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. NEJM 10.1056/NEJMoa1603460. PMID:27276234 Background: Research and guidelines are limited in terms of specific goal blood pressure targets in patients who suffer intracranial hemorrhage, especially those with acute hypertensive responses.